U\u017e d\u0159\u00edve se \u0159\u00edkalo, \u017ee ho dv\u011b v\u00e1\u017en\u00e9 nemoci odsoudily k z\u00e1niku. P\u0159esto je tento 63let\u00fd mu\u017e nyn\u00ed v \u00fapln\u00e9 remisi HIV i rakoviny \u2013 co\u017e je v\u00fdsledek, kter\u00fd je mo\u017en\u00fd d\u00edky s\u00e9rii n\u00e1hod tak mimo\u0159\u00e1dn\u00fdch, \u017ee i jeho l\u00e9ka\u0159i se st\u00e1le sna\u017e\u00ed pochopit jejich v\u00fdznam.<\/p>\n
\u201ePacient z Osla\u201c, jeho\u017e identita z\u016fst\u00e1v\u00e1 utajena, \u017eije s HIV od roku 2006. Jeho virov\u00e1 n\u00e1lo\u017e byla do t\u00e9 doby dob\u0159e kontrolov\u00e1na antiretrovirovou terapi\u00ed. V roce 2017 mu v\u0161ak byla diagnostikov\u00e1na nov\u00e1 diagn\u00f3za: myelodysplastick\u00fd syndrom, obzvl\u00e1\u0161t\u011b agresivn\u00ed rakovina krve, kter\u00e1 naru\u0161uje tvorbu krvinek v kostn\u00ed d\u0159eni. Bez transplantace byl jeho \u017eivot prakticky v ohro\u017een\u00ed.<\/p>\n
L\u00e9ka\u0159sk\u00fd t\u00fdm Univerzitn\u00ed nemocnice v Oslu pot\u00e9 zah\u00e1jil intenzivn\u00ed hled\u00e1n\u00ed kompatibiln\u00edho d\u00e1rce. Jejich po\u010d\u00e1te\u010dn\u00ed strategie se zam\u011b\u0159ila na identifikaci d\u00e1rce nesouc\u00edho mutaci CCR5-delta32, co\u017e je vz\u00e1cn\u00e1 genetick\u00e1 anom\u00e1lie, kter\u00e1 prop\u016fj\u010duje p\u0159irozenou rezistenci v\u016f\u010di HIV \u2013 vlastnost, kterou m\u00e1 pouze asi 1 % populace severn\u00ed Evropy. Tv\u00e1\u0159\u00ed v tv\u00e1\u0159 selh\u00e1n\u00ed tohoto prvn\u00edho p\u0159\u00edstupu se l\u00e9ka\u0159i obr\u00e1tili na star\u0161\u00edho bratra pacienta v nad\u011bji, \u017ee dojde k lep\u0161\u00ed genetick\u00e9 shod\u011b.<\/p>\n
V den transplantace v roce 2020 l\u00e9ka\u0159i s \u00fa\u017easem zjistili, \u017ee bratr d\u00e1rce s\u00e1m je nositelem mutace CCR5. Minim\u00e1ln\u00ed \u0161ance v oblasti sv\u011bta, kde postihuje pouze jednoho ze sta lid\u00ed. S\u00e1m pacient situaci shrnul pozoruhodnou fr\u00e1z\u00ed: \u201eBylo to, jako bych dvakr\u00e1t vyhr\u00e1l v loterii.\u201c<\/em><\/p>\n Poopera\u010dn\u00ed anal\u00fdzy postupn\u011b potvrdily \u00fa\u010dinnost transplantace. Dva roky po z\u00e1kroku \u201epacient z Osla\u201c pod p\u0159\u00edsn\u00fdm l\u00e9ka\u0159sk\u00fdm dohledem ukon\u010dil antiretrovirovou l\u00e9\u010dbu. N\u00e1sledn\u00e9 testy pak neodhalily \u017e\u00e1dn\u00e9 dal\u0161\u00ed stopy viru v jeho krvi, st\u0159evech ani m\u00ed\u0161e. Jeho p\u0159\u00edpad byl ofici\u00e1ln\u011b podrobn\u011b pops\u00e1n<\/a> ve studii publikovan\u00e9 13. dubna 2026 v \u010dasopise Nature Microbiology.<\/p>\n \u201ePacient z Osla\u201c se p\u0159ipojuje k velmi mal\u00e9mu mezin\u00e1rodn\u00edmu seznamu \u2013 takzvan\u00fdm pacient\u016fm z Berl\u00edna, Lond\u00fdna, D\u00fcsseldorfu, New Yorku, M\u011bsta nad\u011bje a \u017denevy \u2013 kte\u0159\u00ed jsou v\u0161ichni pova\u017eov\u00e1ni za vyl\u00e9\u010den\u00e9 nebo v trval\u00e9 remisi HIV po transplantaci kostn\u00ed d\u0159en\u011b ur\u010den\u00e9 k l\u00e9\u010db\u011b rakoviny. V\u0161ichni sd\u00edlej\u00ed stejnou charakteristiku: d\u00e1rce je nositelem ochrann\u00e9 mutace CCR5, s v\u00fdjimkou pacienta z \u017denevy, jeho\u017e p\u0159\u00edpad zkoum\u00e1 jin\u00e9 mechanismy.<\/p>\n V\u00fdzkumn\u00edci a l\u00e9ka\u0159i, kte\u0159\u00ed se na tom pod\u00edlej\u00ed, v\u0161ak nal\u00e9haj\u00ed na maxim\u00e1ln\u00ed opatrnost. Transplantace kostn\u00ed d\u0159en\u011b je i nad\u00e1le slo\u017eit\u00fd a rizikov\u00fd z\u00e1krok, spojen\u00fd s v\u00fdznamnou \u00famrtnost\u00ed a velmi z\u00e1va\u017en\u00fdmi vedlej\u0161\u00edmi \u00fa\u010dinky. Jej\u00ed \u00famrtnost m\u016f\u017ee za ur\u010dit\u00fdch okolnost\u00ed dos\u00e1hnout 20 %. Nicm\u00e9n\u011b tyto p\u0159\u00edpady z\u016fst\u00e1vaj\u00ed neoceniteln\u00fdmi \u201e\u017eiv\u00fdmi laborato\u0159emi\u201c pro v\u00fdzkum a nab\u00edzej\u00ed mo\u017enosti pochopen\u00ed mechanism\u016f, kter\u00e9 by n\u00e1m jednoho dne mohly umo\u017enit kontrolovat nebo dokonce trvale vym\u00fdtit HIV.<\/p>\n Stru\u010dn\u011b \u0159e\u010deno, tento pacient, p\u0159ezd\u00edvan\u00fd \u201epacient z Osla\u201c, vzdoruje l\u00e9ka\u0159sk\u00fdm statistik\u00e1m. Jeho p\u0159\u00edb\u011bh ilustruje, jak ur\u010dit\u00e9 terapeutick\u00e9 pokroky vznikaj\u00ed z v\u00fdjime\u010dn\u00fdch okolnost\u00ed, kde se biologie, medic\u00edna a n\u00e1hoda prot\u00ednaj\u00ed t\u00e9m\u011b\u0159 neopakovateln\u00fdm zp\u016fsobem.<\/p>\n","protected":false},"excerpt":{"rendered":"U\u017e d\u0159\u00edve se \u0159\u00edkalo, \u017ee ho dv\u011b v\u00e1\u017en\u00e9 nemoci odsoudily k z\u00e1niku. P\u0159esto je tento 63let\u00fd mu\u017e nyn\u00ed...","protected":false},"author":8375,"featured_media":439738,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"disable_msn":false,"footnotes":""},"categories":[5639],"tags":[],"class_list":["post-439713","post","type-post","status-publish","format-standard","has-post-thumbnail","category-bien-etre"],"image":{"medium":["https:\/\/www.ma-grande-taille.com\/wp-content\/uploads\/2026\/04\/Charlss-GonzHu-_-Pexels-200x113.jpg",200,113,true],"large":["https:\/\/www.ma-grande-taille.com\/wp-content\/uploads\/2026\/04\/Charlss-GonzHu-_-Pexels-500x281.jpg",500,281,true]},"custom":{"td_video":"","featured_image":"https:\/\/www.ma-grande-taille.com\/wp-content\/uploads\/2026\/04\/Charlss-GonzHu-_-Pexels.jpg","author":{"name":"Fabienne Baure","avatar":"https:\/\/www.ma-grande-taille.com\/wp-content\/uploads\/2026\/10\/fabienne_baure-96x96.jpg"},"categories":[{"term_id":5639,"name":"Pohoda","slug":"bien-etre","term_group":0,"term_taxonomy_id":5804,"taxonomy":"category","description":" Rubrika Pohoda v magaz\u00ednu The Body Optimist p\u0159in\u00e1\u0161\u00ed praktick\u00e9 rady, jak se h\u00fdbat, l\u00e9pe sp\u00e1t, zvl\u00e1dat stres a rozum\u011bt drobn\u00fdm ka\u017edodenn\u00edm pot\u00ed\u017e\u00edm. Je ur\u010den\u00e1 v\u0161em \u017een\u00e1m a v\u0161em postav\u00e1m a vych\u00e1z\u00ed z jednoduch\u00e9 my\u0161lenky: p\u00e9\u010de o t\u011blo stoj\u00ed na radosti a pravidelnosti, ne na tlaku a v\u00fd\u010ditk\u00e1ch.<\/p>\n P\u0159i n\u00e1vratu k pohybu se vyplat\u00ed s\u00e1zet na pravidelnost, ne na intenzitu. P\u00e1r vod\u00edtek pro pozvoln\u00fd za\u010d\u00e1tek:<\/p>\n Za pohyb se po\u010d\u00edtaj\u00ed i b\u011b\u017en\u00e9 ka\u017edodenn\u00ed \u010dinnosti, nap\u0159\u00edklad ch\u016fze nebo j\u00edzda na kole do pr\u00e1ce \u010di na n\u00e1kup.<\/p>\n T\u011blo tu nen\u00ed projekt k oprav\u011b. O sportu mluv\u00edme kv\u016fli radosti, n\u00e1lad\u011b a zdrav\u00ed, nikdy jako o zp\u016fsobu, jak \u201evykompenzovat\u201c j\u00eddlo nebo zhubnout, a ka\u017ed\u00e1 rada mus\u00ed fungovat bez ohledu na tvou postavu. \u010cl\u00e1nky v t\u00e9to rubrice maj\u00ed obecn\u011b informa\u010dn\u00ed charakter a nenahrazuj\u00ed radu zdravotn\u00edka.<\/p>\n Sv\u011btov\u00e1 zdravotnick\u00e1 organizace doporu\u010duje dosp\u011bl\u00fdm alespo\u0148 150 minut st\u0159edn\u011b intenzivn\u00ed vytrvalostn\u00ed aktivity t\u00fddn\u011b, nap\u0159\u00edklad rychl\u00e9 ch\u016fze. Z\u00e1rove\u0148 zd\u016fraz\u0148uje, \u017ee trocha pohybu je lep\u0161\u00ed ne\u017e \u017e\u00e1dn\u00fd: po\u010d\u00edt\u00e1 se ka\u017ed\u00e1 aktivita, i kr\u00e1tk\u00e1, a nejd\u016fle\u017eit\u011bj\u0161\u00ed je naj\u00edt tempo, kter\u00e9 dlouhodob\u011b udr\u017e\u00ed\u0161.<\/p>\n Prvn\u00edm krokem je pravidelnost: chodit sp\u00e1t a vst\u00e1vat p\u0159ibli\u017en\u011b ve stejnou dobu, i o v\u00edkendu. Us\u00edn\u00e1n\u00ed usnadn\u00ed tich\u00e1, tmav\u00e1 a chladn\u011bj\u0161\u00ed lo\u017enice, m\u00e9n\u011b obrazovek ve\u010der a ne p\u0159\u00edli\u0161 pozdn\u00ed ve\u010de\u0159e. Hlasit\u00e9 chr\u00e1p\u00e1n\u00ed nebo probouzen\u00ed s pocitem du\u0161en\u00ed je d\u016fvod probrat to s l\u00e9ka\u0159em.<\/p>\n Dlouhodob\u00e1 \u00fanava m\u016f\u017ee m\u00edt mnoho p\u0159\u00ed\u010din: nedostatek sp\u00e1nku, stres, ment\u00e1ln\u00ed p\u0159et\u00ed\u017een\u00ed, ale tak\u00e9 nedostatek \u017eeleza, poruchu \u0161t\u00edtn\u00e9 \u017el\u00e1zy nebo depresi. Pokud trv\u00e1 n\u011bkolik t\u00fddn\u016f navzdory odpo\u010dinku nebo ji doprov\u00e1zej\u00ed dal\u0161\u00ed p\u0159\u00edznaky, zajdi k l\u00e9ka\u0159i a hledejte jej\u00ed p\u0159\u00ed\u010dinu spole\u010dn\u011b.<\/p>\n Chce\u0161 j\u00edt d\u00e1l? V\u0161echna t\u00e9mata najde\u0161 v rubrice Zdrav\u00ed<\/a>, nast\u00e1vaj\u00edc\u00ed maminky prov\u00e1z\u00ed rubrika T\u011bhotenstv\u00ed<\/a> a pestr\u00e9 j\u00eddlo bez restrikc\u00ed nab\u00edz\u00ed rubrika V\u00fd\u017eiva<\/a>.<\/p>","parent":360,"count":1718,"filter":"raw","cat_ID":5639,"category_count":1718,"category_description":" Rubrika Pohoda v magaz\u00ednu The Body Optimist p\u0159in\u00e1\u0161\u00ed praktick\u00e9 rady, jak se h\u00fdbat, l\u00e9pe sp\u00e1t, zvl\u00e1dat stres a rozum\u011bt drobn\u00fdm ka\u017edodenn\u00edm pot\u00ed\u017e\u00edm. Je ur\u010den\u00e1 v\u0161em \u017een\u00e1m a v\u0161em postav\u00e1m a vych\u00e1z\u00ed z jednoduch\u00e9 my\u0161lenky: p\u00e9\u010de o t\u011blo stoj\u00ed na radosti a pravidelnosti, ne na tlaku a v\u00fd\u010ditk\u00e1ch.<\/p>\n P\u0159i n\u00e1vratu k pohybu se vyplat\u00ed s\u00e1zet na pravidelnost, ne na intenzitu. P\u00e1r vod\u00edtek pro pozvoln\u00fd za\u010d\u00e1tek:<\/p>\n Za pohyb se po\u010d\u00edtaj\u00ed i b\u011b\u017en\u00e9 ka\u017edodenn\u00ed \u010dinnosti, nap\u0159\u00edklad ch\u016fze nebo j\u00edzda na kole do pr\u00e1ce \u010di na n\u00e1kup.<\/p>\n T\u011blo tu nen\u00ed projekt k oprav\u011b. O sportu mluv\u00edme kv\u016fli radosti, n\u00e1lad\u011b a zdrav\u00ed, nikdy jako o zp\u016fsobu, jak \u201evykompenzovat\u201c j\u00eddlo nebo zhubnout, a ka\u017ed\u00e1 rada mus\u00ed fungovat bez ohledu na tvou postavu. \u010cl\u00e1nky v t\u00e9to rubrice maj\u00ed obecn\u011b informa\u010dn\u00ed charakter a nenahrazuj\u00ed radu zdravotn\u00edka.<\/p>\n Sv\u011btov\u00e1 zdravotnick\u00e1 organizace doporu\u010duje dosp\u011bl\u00fdm alespo\u0148 150 minut st\u0159edn\u011b intenzivn\u00ed vytrvalostn\u00ed aktivity t\u00fddn\u011b, nap\u0159\u00edklad rychl\u00e9 ch\u016fze. Z\u00e1rove\u0148 zd\u016fraz\u0148uje, \u017ee trocha pohybu je lep\u0161\u00ed ne\u017e \u017e\u00e1dn\u00fd: po\u010d\u00edt\u00e1 se ka\u017ed\u00e1 aktivita, i kr\u00e1tk\u00e1, a nejd\u016fle\u017eit\u011bj\u0161\u00ed je naj\u00edt tempo, kter\u00e9 dlouhodob\u011b udr\u017e\u00ed\u0161.<\/p>\n Prvn\u00edm krokem je pravidelnost: chodit sp\u00e1t a vst\u00e1vat p\u0159ibli\u017en\u011b ve stejnou dobu, i o v\u00edkendu. Us\u00edn\u00e1n\u00ed usnadn\u00ed tich\u00e1, tmav\u00e1 a chladn\u011bj\u0161\u00ed lo\u017enice, m\u00e9n\u011b obrazovek ve\u010der a ne p\u0159\u00edli\u0161 pozdn\u00ed ve\u010de\u0159e. Hlasit\u00e9 chr\u00e1p\u00e1n\u00ed nebo probouzen\u00ed s pocitem du\u0161en\u00ed je d\u016fvod probrat to s l\u00e9ka\u0159em.<\/p>\n Dlouhodob\u00e1 \u00fanava m\u016f\u017ee m\u00edt mnoho p\u0159\u00ed\u010din: nedostatek sp\u00e1nku, stres, ment\u00e1ln\u00ed p\u0159et\u00ed\u017een\u00ed, ale tak\u00e9 nedostatek \u017eeleza, poruchu \u0161t\u00edtn\u00e9 \u017el\u00e1zy nebo depresi. Pokud trv\u00e1 n\u011bkolik t\u00fddn\u016f navzdory odpo\u010dinku nebo ji doprov\u00e1zej\u00ed dal\u0161\u00ed p\u0159\u00edznaky, zajdi k l\u00e9ka\u0159i a hledejte jej\u00ed p\u0159\u00ed\u010dinu spole\u010dn\u011b.<\/p>\n Chce\u0161 j\u00edt d\u00e1l? V\u0161echna t\u00e9mata najde\u0161 v rubrice Zdrav\u00ed<\/a>, nast\u00e1vaj\u00edc\u00ed maminky prov\u00e1z\u00ed rubrika T\u011bhotenstv\u00ed<\/a> a pestr\u00e9 j\u00eddlo bez restrikc\u00ed nab\u00edz\u00ed rubrika V\u00fd\u017eiva<\/a>.<\/p>","cat_name":"Pohoda","category_nicename":"bien-etre","category_parent":360}]},"_links":{"self":[{"href":"https:\/\/www.ma-grande-taille.com\/cs\/wp-json\/wp\/v2\/posts\/439713","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ma-grande-taille.com\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ma-grande-taille.com\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ma-grande-taille.com\/cs\/wp-json\/wp\/v2\/users\/8375"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ma-grande-taille.com\/cs\/wp-json\/wp\/v2\/comments?post=439713"}],"version-history":[{"count":3,"href":"https:\/\/www.ma-grande-taille.com\/cs\/wp-json\/wp\/v2\/posts\/439713\/revisions"}],"predecessor-version":[{"id":439775,"href":"https:\/\/www.ma-grande-taille.com\/cs\/wp-json\/wp\/v2\/posts\/439713\/revisions\/439775"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ma-grande-taille.com\/cs\/wp-json\/wp\/v2\/media\/439738"}],"wp:attachment":[{"href":"https:\/\/www.ma-grande-taille.com\/cs\/wp-json\/wp\/v2\/media?parent=439713"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ma-grande-taille.com\/cs\/wp-json\/wp\/v2\/categories?post=439713"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ma-grande-taille.com\/cs\/wp-json\/wp\/v2\/tags?post=439713"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}} Potvrzen\u00e1 remise dva roky po operaci<\/h2>\n
Je\u0161t\u011b jedno jm\u00e9no na velmi kr\u00e1tk\u00e9m seznamu<\/h2>\n
L\u00e9ka\u0159sk\u00e1 nad\u011bje, ale ne l\u00e9\u010dba, kterou lze \u0161iroce pou\u017e\u00edvat<\/h2>\n
Co najde\u0161 v rubrice Pohoda<\/h2>\n
\n
Jak se vr\u00e1tit ke sportu po dlouh\u00e9 pauze?<\/h2>\n
\n
N\u00e1\u0161 p\u0159\u00edstup<\/h2>\n
\u010cl\u00e1nky pro za\u010d\u00e1tek<\/h2>\n
\n
\u010cast\u00e9 ot\u00e1zky<\/h2>\n
Kolik pohybu t\u00fddn\u011b pot\u0159ebuju?<\/h3>\n
Jak se l\u00e9pe vyspat?<\/h3>\n
Pro\u010d jsem po\u0159\u00e1d unaven\u00e1?<\/h3>\n
Co najde\u0161 v rubrice Pohoda<\/h2>\n
\n
Jak se vr\u00e1tit ke sportu po dlouh\u00e9 pauze?<\/h2>\n
\n
N\u00e1\u0161 p\u0159\u00edstup<\/h2>\n
\u010cl\u00e1nky pro za\u010d\u00e1tek<\/h2>\n
\n
\u010cast\u00e9 ot\u00e1zky<\/h2>\n
Kolik pohybu t\u00fddn\u011b pot\u0159ebuju?<\/h3>\n
Jak se l\u00e9pe vyspat?<\/h3>\n
Pro\u010d jsem po\u0159\u00e1d unaven\u00e1?<\/h3>\n